Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans
نویسندگان
چکیده
منابع مشابه
Innate Immunity to Leishmania Infection: Within Phagocytes
Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for monocytes and dendritic cells. This paper addresses recent experimental findin...
متن کاملImmune response to Leishmania infection.
Antileishmanial immune response is shown to be host genotype dependent so that some inbred strains of mouse are susceptible while others are resistant. The resistance is conferred by T-helper type-1 (Th1) cells while the susceptibility is conferred by Th2 cells. Th1 cells secrete IL-2 and IFN-gamma but Th2 cells secrete IL-4, IL-5 and IL-10. It has been shown that IFN-gamma activates macrophage...
متن کاملLeishmania (Leishmania) amazonenis Infection, Suriname
sociated with several days of heavy rainfall from typhoons. Therefore, the typhoons may be the reason for high incidence in October–December. The annual incidence of leptospirosis in Taiwan is relatively lower than that in other countries with tropical or subtropical climates. Our study does not conclusively document the reason for lower incidence, although it does suggest an association betwee...
متن کاملResistance to Leishmania major in Mice.
to Leishmania major in mice is a topic of interest to many imMLunologists attempting to link the immunological mechanism with the responsible genes. In this respect, this experimental system is one of the paradigms for genetics of disease susceptibility. Mehmet L. Giuler et al. (1) question the hypothesis that production of in-terleUkin-4 (IL-4) with subsequent generation of a T helper cell typ...
متن کاملConstitutional and non-specific immunity to infection.
Most immunologists focus on elaborate non-specific and antigen-specific factors of reactive immunity produced by the vertebrate lymphoid system. Modern principles of immunogenic prophylaxis and therapy are based solely on the use of these agents. There is, however, a more effective system of specific resistance which is shared by all forms of life: hereditary constitutional immunity to infectio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2008
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.1992.tb06413.x